The game is currently in development, but one of the major challenges will be creating a world that feels believable and immersive.

The “types of muscles” is a term that refers to the different types of muscle tissue found in the human body. There are three main types of muscle: skeletal, cardiac and smooth.

Vintage man lifting barbell with heavy weights above head.

Note from the editor: This is a guest post by Kamal Patel.

Supplements that claim to develop muscle are a booming business, from testosterone boosters to horny goat weed. They’re all sold in the same way: purchase this product, become jacked, lose fat, appear hotter, and be more successful in life.

How many of those pills, on the other hand, genuinely help you gain muscle? Just because some of them helped a diabetic lab mouse gain muscle over the course of two weeks doesn’t indicate you’ll get the same results. Animal research is an excellent approach to lay the groundwork for future human investigations, but it is not a replacement.

Building muscle is influenced by what you eat, how you exercise, how much sleep you receive, and what supplements you take. Just remember that supplements aren’t nearly as important as a healthy diet, regular exercise, and adequate sleep. Those three are the cornerstones of your foundation. If your workout regimen is regular, your diet is nutritious and includes adequate protein, and you receive enough quality sleep, you may still gain muscle without supplements. Supplements are merely the cherry on top. They’ll encourage you to work a little harder.

So, which supplements are effective?

Most Likely to Work


There’s a reason why creatine is so popular. It increases muscle protein synthesis and boosts power output, both of which contribute to muscular development.

What is the mechanism of creatine action? Creatine functions as an additional reservoir for phosphate groups, for those who remember their high school biology. Creatine may aid transfer phosphate to ADP when your body runs out of easily accessible ATP (for example, while lifting weights) (to give your body more ATP). In terms of practical use, creatine essentially offers your cells a boost in energy.

Taking creatine might also result in a 5-10 pound increase in water weight. Muscle cells develop quicker as a result of the higher water stress. This is one of the reasons why creatine supplementation promotes long-term muscular development. Because novice weightlifters have more muscle to build, they profit more from creatine than seasoned athletes. (This isn’t to say that athletes shouldn’t take creatine.)

Creatine is inexpensive, healthful, and offers a number of advantages (as it is essentially cellular energy, it has been linked to benefits to overall health). Some individuals may not benefit from creatine supplementation since not everyone reacts favorably to it. When compared to inactive persons, athletes are more likely to react to creatine.

Powdered Protein

Protein powder is a well-liked dietary supplement. Though the original protein powders tasted like chalk, today’s powders are inexpensive and tasty. They’re as excellent as or better than other protein sources in terms of bioavailability and amino acid balance, which makes them ideal for eating chocolate while maintaining a chicken-like nutritional profile. Whey and casein protein are derived from milk and may be used as a dehydrated food source. They’re also rich in calcium.


Protein supplements aren’t very noteworthy, but they may help you acquire enough protein in your diet. Protein powder is a convenient technique to increase muscle growth and strength.

Potentially Beneficial


Although beta-alanine isn’t as effective as creatine, it’s worth a shot if you’re serious about reaching your full potential. Beta-alanine is an amino acid that the muscles convert to carnosine. Carnosine protects muscle cells against acidity, such as those generated during strenuous exercise.

Supplementing with beta-alanine is most helpful for athletes who workout for 60-240 seconds. Supplementation gives a minor performance increase (2-3 percent), making it suitable for athletes looking to improve their times by a few seconds.

Supplementing with beta-alanine boosts endurance and the amount of work that can be done in one go, which is beneficial for lifters who prefer shorter rest periods and longer sets. Keep in mind that beta-alanine has no effect on power output (unlike creatine).

Even after controlling for the additional work beta-alanine supplemented persons might perform in the gym, researchers found an increase in muscle development following beta-alanine supplementation in one study. That implies, in addition to increasing endurance, beta-alanine may help you gain muscle.

My Podcast With Kamal Patel on the Real Science of Nutrition and Supplements


It Isn’t Likely to Work

Amino Acids with Branched Chains (BCAAs)

BCAAs are a kind of amino acid that boosts muscle protein synthesis. Supplementing BCAAs has little practical use since you already consume BCAAs every time you eat a protein-rich food. Lifters’ favorite protein sources, such as whey or beef, are often rich in BCAAs.

They may be advantageous if you exercise while fasting, but it’s cheaper and simpler to stick to actual food since consuming a little extra protein at your next meal is almost as effective. If you do decide to purchase BCAA powder, it is advised that you do so in a flavored variety.

Boosters of Nitric Oxide

Nitric oxide boosters are a group of supplements rather than a single product. L-arginine, L-citrulline, and agmatine are all popular supplements in this category.

Increased nitric oxide levels boost satellite cell proliferation (which aids in the formation of new muscle cells), enhance blood flow by relaxing blood vessels, and boost mitochondrial efficiency. All of these impacts have the potential to increase muscle mass.

However, when it comes to supplementation, nitric oxide boosters have a long way to go. The amount of L-arginine that the body can absorb is limited. In your body, L-citrulline is converted to L-arginine, and therefore the rate limit is reached once again. As a result, neither supplement is effective in increasing nitric oxide levels in the blood. Agmatine hasn’t been tested on humans, and there’s no proof that it can help you develop muscle. Manipulation of nitric oxide levels may be a smart approach to gain muscle, but existing pills won’t help.

Beta-Hydroxy-Beta-Methylbutyrate is a kind of beta-hydroxybutyrate (HMB)

HMB is a metabolite that is created when the body breaks down leucine (a BCAA). HMB is considered to inhibit catabolism, or the breakdown of muscle protein.


Unfortunately, it has little effect on athletic performance, is not more anabolic than leucine, and does not aid muscle growth. HMB might help maintain muscle mass under calorie restriction, however additional study is required to see whether this effect is practical. One caveat: a research released in early 2014 found that utilizing free form HMB during intensive lifting cycles resulted in significant muscular and strength improvements (but not during caloric restriction). Because the majority of HMB products on the market as of summer 2014 do not employ this form, they will not provide the advantages shown in the research. Furthermore, the conclusions of this research have not been repeated, so buyer beware.

Not Recommended/Ineffective

Gainers of mass

Protein powders are fantastic, but what happens when you add a ton of sugar, fatty acids, and a 200 percent price increase? The bulk gainer shelf may be found at your local supplement shop.

Protein powders with too many additives are known as mass gainers. They’re sold to folks who don’t comprehend that a protein shake may be had without ingesting the equivalent of several candy bars.

Instead of utilizing a bulk gainer, make a protein drink with oats, yogurt, and berries. It’s better for you and tastes better as well.

It’s also a lot less expensive.


Glutamine is essential for muscle cell function, and injecting it into a muscle cell would almost certainly result in growth. But what about oral supplementation? There was no such luck.

After oral supplementation, glutamine is maintained by the intestines and liver, which give glutamine to the body as required. Glutamate for athletes has been studied extensively, however it has repeatedly failed to improve muscle growth.

Keep Calm and Keep Lifting

That should cover the majority of the popular muscle-building pills on the market. We decided to postpone the testosterone boosters until tomorrow since they need a more detailed explanation.

There aren’t many muscle-building pills that live up to the promise, as you can see. The fact is that the principles of muscle gain are still the same: lift heavy, consume a lot of food (especially protein), and get adequate sleep. Remember that supplements are meant to be used in conjunction with a good foundation.

All of our citations may be seen on

All of our citations may be seen on’s director is Kamal Patel. He graduated from Johns Hopkins University with an MBA and an MPH (Master of Public Health), and he was working on his PhD in nutrition when he decided to join He is committed to bringing scientific studies in the fields of nutrition and supplements available to the general public.



Muscle alignment is a term used to describe how muscles are arranged and positioned in the human body. It can also be used to refer to the orientation of bones relative to each other. Reference: muscle alignment.

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  • muscle tissue
  • skeletal muscle
  • cardiac muscle
  • muscle diagram
  • muscle function